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KMID : 1161920170140020045
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Journal of Medicine and Life Science
2017 Volume.14 No. 2 p.45 ~ p.47
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The analysis of myeloid-derived suppressor cells in cancer patients with neutropenia to evaluate the effect of granulocytes colony stimulation factor
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Yang Sun-Woo
Han Sang-Hoon
Kim Young-Ree
Kim Sun-Hyung
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Abstract
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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population associated with immunosuppression and inflammation in cancer patients. Granulocytes colony stimulating factor (G-CSF) is frequently used in cancer patients with neutropenia. To evaluate the effect of G-CSF on patients being chemotherapy, we analyzed MDSCs in the peripheral blood. Peripheral blood was collected from 13 patients accompanied neutropenia during chemotherapy before and after G-CSF administration. Flow cytometry was used to examine the percentage of MDSCs. The changes of MDSCs in the peripheral blood according to G-CSF infusion were analyzed. The absolute neutrophil counts in patients before G-CSF administration were 560±353 cells/uL (59-1,102 cells/uL). MDSCs were detected in the peripheral mononuclear cells with a cell percentage of 2.74±4.02% (0.2-12.2%) and 5.48±8.56% (0.2-26.9%) before and after G-CSF infusion, respectively. Although there is no statistically significance, G-CSF generally seems to move the MDSCs from the bone marrow to the peripheral blood to increase MDSCs in the peripheral blood. It is necessary to study how the increased MDSCs affect the patient’s prognosis.
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KEYWORD
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Myeloid-derived suppressor cells (MDSCs), Neutropenia, Granulocytes colony stimulating factor (G-CSF)
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